Used by a number of compact and mid-range vehicles, 205/45 R16 tyres have a relatively low profile for this class. These products often focus on low rolling resistance, as eco tyres are becoming increasingly popular. The first number in this description indicates that cross-section width (the distance between sidewalls) is 205 millimetres.
Connected to this is the number 45, indicating aspect ratio. This gives us the height of the sidewall as a percentage of cross-section width. Here, sidewall height is 45% of 205 mm. Generally speaking, aspect ratios lower than 50 describe low profiles, which allow for larger rim sizes and better handling - but often somewhat reduced ride comfort.
The letter R informs us that this is a radial tyre, as the vast majority of light vehicle tyres are. The final indicator, the number 16, is a measure of inner diameter. It essentially means that you will need 16 inch rims to fit tyres of this size.